Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates

Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates.

Reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI), and cytokines are frequent companions at sites of acute inflammation. Previous work has established a clear link between the production of cytokines and the subsequent generation of ROI and RNI. However, more recent data indicates that ROI and RNI not only serve as end-stage effector molecules of pathogen destruction an...

Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates.

IN THIS ISSUE of AJP-Lung, Kaestle et al. (28) report that an increase in left atrial pressure in isolated perfused lungs induces a Ca -dependent increase of endothelial nitric oxide (NO) production, which decreases reabsorption of fluid across the alveolar epithelium, resulting in pulmonary edema. Furthermore, they report that in chronic heart failure, NO production by endothelial cells is imp...

Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates.

BACKGROUND Mycobacterium tuberculosis is a significant human pathogen capable of replicating in mononuclear phagocytic cells. Exposure to reactive oxygen and nitrogen intermediates is likely to represent an important aspect of the life cycle of this organism. The response of M. tuberculosis to these agents may be of significance for its survival in the host. MATERIALS AND METHODS Patterns of ...

Reactive nitrogen and oxygen intermediates in patients with cutaneous leishmaniasis.

The metabolisms of reactive nitrogen and oxygen intermediates (RNI and ROI) in patients with cutaneous leishmaniasis (CL) were investigated and compared with those of healthy subjects. To determine RNI metabolism, nitrite plus nitrate concentrations were measured spectrophotometrically. Nitrite concentration in plasma was determined directly by the Griess method. Nitrate levels in plasma were m...

SnapShot: Reactive Oxygen Intermediates (ROI)